Etomidate - 3
Metabolism
In the liver:
 etomidate |
---> ester hydrolysis (MAJOR) |
 carboxylic acid of etomidate |
| ---> N-dealkylation (minor) |
 ethyl-imidazole-5-carbolylate |
The major metabolite, the carboxylic acid of etomidate, is inactive. Etomidate metabolites are excreted in the urine (85%) and bile (15%).