Intravenous Anesthesia - Ketamine

Ketamine - 3

Metabolism

Ketamine is metabolized by the hepatic microsomal system.

Major pathway:

	N-demethylation ->
ketamine		norketamine (metabolite I)

Norketamine, with 20-30% of the activity of ketamine, is hydroxlyated to hydoxynorketamine, conjugated with glucuronate and excreted in the urine. Norketamine, with t_1/2(elimination) = 6 hours, probably contributes significantly to analgesia.

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